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第５回ＣＯＥ(自己組織系物理)セミナー ［通算第5回］
| Function of Motor Proteins at Single Molecule Level. |
| 日 時 |
2004年3月6日（土） 14時00分〜15時30分 |
| 場 所 |
早稲田大学理工学部大久保キャンパス62号館中会議室 [地図] |
| 講演者 |
Prof. Bernhard Brenner
(Molecular and Cell Physiology,Medical School of Hannover,Hannover,Germany) |
| 講演要旨 |
The goal of our work is to understand the molecular mechanisms of motile functions at the level of the individual motor
molecule. This requires identifying and characterizing the essential intermediate states and the most essential reaction
steps in the cyclic function of motor proteins. Thus, we have to characterize and correlate mechanical properties of the
intermediate states, their (bio)chemical identity and structural properties, and we have to characterize of the kinetics
of at least the most essential reaction steps including their strain-dependence to provide the basic data for developing
quantitative models for motor protein function at the single molecule level. In our early work we had to rely on data
collected from large ensembles of motor molecules, single demembranated fibers of the M. psoas of rabbits with all the
difficulties to extrapolate from large ensemble behavior to the individual molecule. Here I will report on our current
status of collecting mechanical, biochemical and structural data from single molecule detection techniques that we have
established in my laboratory.
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| 紹介教員 |
石渡信一 |
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